Estrogen receptor beta as target for colorectal cancer prevention
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چکیده
منابع مشابه
Bioinformatics-Based Prediction of FUT8 as a Therapeutic Target in Estrogen Receptor-Positive Breast Cancer
Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
متن کاملBioinformatics-Based Prediction of FUT8 as a Therapeutic Target in Estrogen Receptor-Positive Breast Cancer
Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
متن کاملColorectal Cancer and Prevention
سرطان کولون و رکتوم یکی از انواع شایع - سابقه ابتلا به سرطان کولورکتال یا پولیپ های سرطانهاست که با وجود ایجاد مشکلات و عوارض متعدد در سلامتی انسانها، هنوز به طور جدی و کافی مورد توجه قرار نگرفته است. به طوریکه در سال ۲۰۰۴ بیش از ۱۳۰ هزار مورد جدید ابتلا به این بیماری در امریکا گزارش شده است. و طبق آمارهای انجمن سرطان آمریکا در سال ۲۰۰۲، از ۱۸۳۳۰۰ مورد ابتلا به سرطان کولورکتال۵۶ هزار مورد ب...
متن کاملEstrogen receptor beta is a novel therapeutic target for photoaging.
One of the many harmful factors faced by the skin is solar UV radiation, which damages skin by inducing chronic low-grade inflammation through increased expression of proinflammatory cytokines, metalloproteinases (MMPs) and cyclooxygenase-2 (COX-2). Estrogen receptors (ERs) alpha and beta are ligand-dependent transcription factors that are expressed in skin, and an ERbeta agonist has previously...
متن کاملEstrogen Receptor Beta Expression in Melanomas Versus Dysplastic Nevi
Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2016
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.12.009